个人基于连接的分片反映了人类听觉皮层的功能性质
Maria Hakonen1,2, Louisa Dahmani1,2, Kaisu Lankinen1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Charlestown, Boston, MA, United States.
Imaging neuroscience (Cambridge, Mass.)
|August 12, 2025
概括
个别的大脑扫描显示了独特的听觉皮层组织. 功能连接映射显示了不同的听觉区域,突出了个人大脑与典型模式的差异,以更好地理解听觉功能.
科学领域:
- 神经成像是一种神经成像.
- 听觉神经科学 听觉神经科学
- 功能连接的功能连接性
背景情况:
- 人类听觉皮层的传统神经成像研究依赖于小组分析,这可能会掩盖个体差异.
- 在个体层面上了解听觉皮层的精确功能组织对于个性化神经科学至关重要.
研究的目的:
- 在人类上皮层 (STC) 中绘制听觉区域,使用个人特定的功能网络分片.
- 评估这些功能分片的可复制性和个体间的变异性.
- 调查个人特定的分片是否比组级分析更好地反映基于任务的听觉功能.
主要方法:
- 在30名参与者中利用了1毫米同位素分辨率的7T功能磁共振成像 (fMRI).
- 在休息状态和听觉/视听语音定位器fMRI数据上使用功能网络分析.
- 在个人和群体层面生成和评估基于功能网络的分片,使用Dice系数和Silhouette值.
主要成果:
- 个体特定的分片显示了适度的个体内可重复性 (69-78%的静止状态,62-73%的静止状态与任务).
- 分片的个体间变异性明显大于个体内变异性 (迪斯系数:57%-68%),捕捉了独特的大脑组织.
- 个别特定的分片显示出与任务响应地形更高的对齐,并在网络内具有更大的连接均性.
结论:
- 上皮质的听觉区域可以根据功能连接性划分为不同的功能子区域.
- 个人级别的功能分片捕捉了听觉皮层组织中的有意义的特异性,优于群体级别的方法.
- 功能连接提供了一个强大的方法来绘制个人的听觉皮层组织,独立于宏观解剖学相似性.
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