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癌症干细胞标记物表达与泰国肝细胞癌患者临床病理特征之间的关联

Supreecha Chattong¹, Pattama Wongsirisin¹, Chanaporn Raman²

¹Department of Medical Research and Technology Assessment, National Cancer Institute, Thailand, Bangkok, THA.

|August 12, 2025

概括

肝细胞癌 (HCC) 呈现出癌症干细胞标志物CD44,CD90,CD133和EpCAM的表达升高. 然而,这些标记物与泰国患者的临床特征或生存结果没有强烈的相关性.

科学领域:

肝胆道手术肝胆道手术
在瘤学瘤学.
癌症干细胞研究研究

背景情况:

肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
癌症干细胞 (CSC) 涉及HCC的发病,进展,转移和治疗耐药性.

研究的目的:

评估泰国HCC患者中CD44,CD90,CD133和EpCAM的表达.
调查这些CSC标记物与临床病理特征和患者存活率的关联.

主要方法:

免疫组织化学 (IHC) 用于分析瘤和相邻的非癌性组织中的CSC标志物表达.
临床病理学数据和整体存活率在接受治疗切除的HCC患者中进行了评估.

主要成果:

所有四个CSC标记物 (CD44,CD90,CD133,EpCAM) 在HCC瘤组织中显著过度表达.
在标记物表达和临床病理学参数之间没有发现显著的关联.
在高和低CSC标志物表达群体之间,整体存活率没有显著差异.

结论:

CD44,CD90,CD133和EpCAM在HCC组织中富含,支持它们在肝癌发生中的作用.
这些CSC标志物与该队列的临床特征和存活率的相关性有限.

关键词:

癌症干细胞是癌症干细胞.在CD133中,CD133中,CD133中,CD133中 cd4444 在线播放 cd90 cd90 在线播放这就是Epcamcam.肝细胞癌是肝细胞癌.

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