血清维生素A和B12水平与加速表观遗传衰老之间的非线性关联
Zhimin Ma1, Mingxing An2, Weiwei Gong1
1Department of Chronic Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Frontiers in nutrition
|August 12, 2025
概括
更高的维生素A摄入量可能会加速衰老,而维生素B12似乎可以防止表观遗传衰老. 这项研究使用DNA甲基化生物标志物探索了营养值和生物衰老.
科学领域:
- 营养科学 营养科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
背景情况:
- 像维生素A和维生素B12这样的微量营养素对于恒常状态至关重要.
- 这些维生素与生物衰老之间的关系尚不清楚.
- 研究营养值及其对衰老的影响至关重要.
研究的目的:
- 研究血清维生素A和B12对加速生物衰老的值效应.
- 用多维DNA甲基化生物标志物来评估衰老.
- 澄清维生素水平与表观遗传衰老指标之间的关联.
主要方法:
- 从国家健康和营养检查调查 (1999-2002) 中对2530名参与者的分析.
- 使用表观遗传时钟 (PhenoAge, GrimAge) 计算年龄加速.
- 应用多变量逻辑回归,通用添加模型和两部分逻辑回归来评估非线性关系.
主要成果:
- 维生素A与PhenoAge和GrimAge加速有非线性关联,较高水平可能加速衰老.
- 维生素B12与PhenoAge加速有非线性关联,表明在适当水平下具有保护作用.
- 确定了维生素A (71.8μg/dL对于GrimAge) 和维生素B12 (488.0 pg/mL对于PhenoAge) 的值效应.
结论:
- 维生素A度升高可能与生物衰老的加快有关.
- 足够的维生素B12摄入量可以防止与年龄相关的表观遗传变化.
- 非线性关系和值效应对于理解维生素衰老动态至关重要.
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