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免疫系统和认知障碍的文献分析:从1985年到2024年的趋势

Beibei Zou¹, Jinxi Xiang², Muhua Zhang¹

¹Department of Cardiology, the Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.

Frontiers in aging neuroscience

|August 12, 2025

概括

研究表明,关于免疫系统功能障碍和认知障碍的研究显著增加. 关键主题包括神经炎症和肠-大脑轴,这表明认知障碍的新治疗点.

科学领域:

免疫学和神经科学交集的跨学科研究.
专注于免疫反应和认知功能之间的复杂相互作用.

背景情况:

认知障碍与免疫系统功能障碍密切相关.
对了解免疫相关认知障碍的机制和治疗途径越来越感兴趣.

研究的目的:

进行对免疫系统和认知障碍研究的图书统计分析.
确定该领域的研究趋势,主要贡献者和新兴主题.

主要方法:

使用Web of Science核心集合对1985年至2024年的3737篇出版物的分析.
使用CiteSpace,VOSviewer和R-bibliometrix进行文献测量分析.
研究了出版趋势,共同撰写,关键词聚类和共同引用模式.

主要成果:

自2021年以来观察到显著的研究产出增长.
美国和中国是主要的贡献者,有着强大的国际合作.
确定了核心主题:神经炎症,微质,肠道微生物群,TREM2和炎症体.
新兴主题包括肠-大脑轴和神经退行性疾病中的免疫调节.

结论:

图书统计分析显示,人们越来越关注神经炎症机制和免疫疗法.
未来的研究很可能会探索肠-免疫-大脑轴和精准医学.
这些发现支持早期检测和针对免疫认知相互作用的新型干预措施的发展.

关键词:

在TREM2中,我们可以使用TREM2.圣经计量资料 (Bibliometric bibliometric bibliometric) 是指参考书目中的资料.共同引文是一种共同引文.认知障碍是一种认知障碍.我们的肠道微生物群.免疫系统免疫系统微质细胞中的微质细胞神经炎症是一种神经炎症.

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