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Updated: Sep 11, 2025

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
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Published on: June 10, 2016

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持续的Yap/Taz激活促进异常的膜上皮细胞分化,并驱动持续的纤维化重塑

Isabella P Gaona1, A Scott McCall1,2, Natalie M Geis1

  • 1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

在膜上皮细胞中持续的YAP/TAZ信号驱动失败的肺修复和异常性肺纤维化 (IPF) 中的纤维化. 阻止这种异常信号促进了适应性修复,为肺纤维化 (PF) 提供了潜在的治疗策略.

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