相关实验视频

Updated: Sep 11, 2025

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

562

引发瘤的遗传学和治疗驱动IDH突变质瘤的分离分子进化

Tamrin Chowdhury, C Mircea S Tesileanu, Emre Kocakavuk

    bioRxiv : the preprint server for biology
    |August 12, 2025
    PubMed
    概括

    在治疗期间,遗传变化驱动IDH突变质瘤的演变. 星系细胞瘤和小类质瘤会发生明显的变化,导致治疗耐药性和这些脑瘤的更糟糕的结果.

    更多相关视频

    Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections05:45

    Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

    Published on: July 31, 2017

    9.7K
    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation09:43

    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

    Published on: January 14, 2014

    8.2K

    相关概念视频

    Tumor Progression02:07

    Tumor Progression

    Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
    Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
    6.5K
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    660
    Adaptive Mechanisms in Cancer Cells02:53

    Adaptive Mechanisms in Cancer Cells

    Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
    Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
    5.9K