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相关概念视频

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Diversity of Antigen Receptors01:28

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
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Rab32-LRMDA-Retriever复合体是肠道免疫恒温的关键调节者.

Ran Song1, Chigozie Ngoka1,2, Amika Singla1

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

bioRxiv : the preprint server for biology
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概括
此摘要是机器生成的。

富含白素的黑色素细胞分化相关蛋白 (LRMDA) 对于肠道免疫恒温至关重要. 与Rab32和Retriever一起工作的LRMDA调节了先天性免疫细胞的内分泌体贩运,防止炎症和感染.

关键词:
德克斯硫酸盐 (DSS) 是一种酸盐.LRMDADA LRMDA 的意思是什么?溶酶体相关器官 (LRO)N-乙烯-N-酸盐urea (ENU) 的使用.Rab32 Rab32 在线阅读收回者可以收回.炎症性肠病 (IBD) 是一种炎症性肠病.这是先天的免疫力.贩卖黄囊,贩卖黄囊的行为.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 微生物学 微生物学

背景情况:

  • 肠道平衡取决于免疫细胞,上皮和微生物组.
  • 天生的免疫细胞必须处理肠道微生物,以防止受伤和感染.
  • 内分泌体系统对于清除微生物和启动炎症反应至关重要.

研究的目的:

  • 为了确定肠道免疫恒温的关键调节者.
  • 了解先天性免疫细胞如何感知和响应肠道微生物.
  • 阐明LRMDA在肠道免疫中的作用.

主要方法:

  • 在ENU转基因小鼠中进行基因查.
  • 鉴定出基因的CRISPR/Cas9验证方法.
  • 血液构造木乃伊和条件淘汰赛小鼠模型.
  • 蛋白质组,细胞和生物化学分析.

主要成果:

  • 鉴定出LRMDA是肠道平衡的一个关键调节剂.
  • LRMDA在CD11c+先天性免疫细胞 (如树突细胞和巨细胞) 中起作用.
  • LRMDA与Rab32和Retriever形成一个复合体,调节内解体体贩运.
  • 失去LRMDA或Retriever会增加对结肠炎和李斯特菌感染的易感性.

结论:

  • 拉布32-LRMDA-Retriever复合体对于内分泌体贩运天生的免疫细胞至关重要.
  • 这种复合体在维持肠道免疫平衡中起着至关重要的作用.
  • 这种途径的干扰可能导致炎症疾病和增加感染易感性.