基于机器学习的新陈代谢调节器的优先级从多omics数据
bioRxiv : the preprint server for biology
|August 12, 2025
概括
人们对癌症代谢的了解很少. 我们的MetaSage管道揭示了癌症代谢物的关键基因和代谢物调节器,提供了新的治疗见解.
科学领域:
- 生物化学 生物化学
- 生物信息学是一种生物信息学.
- 在瘤学瘤学.
背景情况:
- 代谢失调是癌症的一个关键特征.
- 控制癌症新陈代谢的精确机制尚未完全理解.
研究的目的:
- 系统地研究各种癌症类型的代谢调节.
- 开发一个计算框架,用于识别癌症代谢物的关键调节剂.
主要方法:
- 开发了MetaSage,一个基于XGBoost的机器学习管道,集成知识图和多omics数据.
- 分析了来自11种癌症类型的15个队伍的统一数据.
- 利用Shapley值来确定可预测代谢物的调节特征.
主要成果:
- 确定了442种可变代谢物和重要的基因和上游代谢物调节剂.
- 发现了1,146个基因特征和363个前体代谢物作为关键调节剂.
- 网络分析揭示了保存和癌症特异的代谢调节模式.
结论:
- MetaSage提供了一个强大的框架,用于发现癌症中的代谢物调节.
- 这些发现为开发针对癌症代谢的新型治疗策略提供了潜力.
相关概念视频
Regulation of Metabolism
9.9K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.9K
Genomics
37.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.5K
Overview of Metabolism
31.9K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
31.9K


