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Updated: Sep 11, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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在XP-C患者的血液细胞中独特的高自发突变负荷

Gordon Fan-Huang1, Elizabeth L Schmidt2,3, Moonsook Lee1

  • 1Department of Genetics, Albert Einstein College of Medicine, Bronx NY 10461, USA.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

Xeroderma Pigmentosum C组 (XP-C) 患者在血液细胞中表现出高的体质突变率,与DNA修复缺陷有关. 这种先前存在的突变负担有助于XP-C白血病的发展.

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