相关实验视频

Updated: Sep 11, 2025

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
09:32

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

Published on: October 14, 2022

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从2D到4D:一个容器化工作流程和浏览器来探索动态染色体架构

David H Rogers1, Cullen Roth2, Cameron Tauxe1,3

  • 1Information Sciences, Los Alamos National Laboratory, Los Alamos, NM, US.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

4D基因组浏览器工作流简化了从Hi-C数据的3D基因组结构重建,整合了用于动态色素分析的表观遗传信息. 这个工具使研究人员能够访问先进的4D表观遗传学.

关键词:
3D基因组浏览器 3D基因组浏览器3D可视化 3D可视化表观基因组学是指表观基因组学.基因组建模 基因组建模这就是Hi-C.染色体的架构 染色体的架构

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相关概念视频

Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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