在急性和慢性疼痛状态中改变决策:对上下文依赖评估的偏见
bioRxiv : the preprint server for biology
|August 12, 2025
概括
慢性疼痛改变了决策,因为人们越来越依赖最近的历史,而不是综合价值. 这种与疼痛持续时间相关的转变为疼痛慢性化的认知标志物.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 疼痛研究 疼痛研究
背景情况:
- 慢性疼痛与认知缺陷有关,特别是在学习和决策方面.
- 在慢性疼痛患者中,这些变化背后的精确认知机制尚未完全理解.
- 了解这些机制对于制定有针对性的干预措施至关重要.
研究的目的:
- 在强化学习框架内调查慢性疼痛对决策过程的影响.
- 在选择行为中区分全球预期价值与近期强化历史的作用.
- 为了确定与疼痛慢性化相关的潜在认知标志物.
主要方法:
- 对239名患有慢性疼痛,急性疼痛或没有疼痛的参与者进行了强化学习任务.
- 该任务将基于全球预期价值的选择与特定背景的强化历史分离.
- 计算建模,特别是混合模型,用于分析行为数据.
主要成果:
- 所有组的学习表现都相似 (慢性疼痛,急性疼痛,没有疼痛).
- 患有慢性疼痛的个体表现出更多地依赖最近的强化史和减少使用综合价值表示.
- 与对照组相比,慢性疼痛组对全球预期值的重量明显较小.
- 急性疼痛组表现出一种中间模式,表明过渡状态.
结论:
- 慢性疼痛与估值策略的转变有关,偏爱最近的历史而不是综合价值.
- 这种改变的决策策略与疼痛的持续时间有关,而不是强度.
- 这些发现表明一种认知机制有助于慢性疼痛的不适应行为,并提供疼痛慢性化的标志物.
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