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Updated: Sep 11, 2025

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
08:40

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

Published on: May 2, 2019

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在ERMCS中,GLP-1R与VAPB和SPHKAP结合,调节β细胞线粒体重塑和功能

Gregory Austin1, Affiong I Oqua1, Liliane El Eid1

  • 1Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

类似葡萄糖-1受体激动剂通过增强线粒体健康来改善胰腺β细胞功能. 这涉及ER-线粒体接触点的新信号通路,对于预防2型糖尿病至关重要.

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High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

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Author Spotlight: Assessment of Mitophagy Flux in Pancreatic β-Cells Using Effective and Robust Complementary Approaches07:04

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