AMPA

Hana Goldschmidt Merrion1, Casey N Barber1, Santosh S Renuse2

  • 1Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

概括

研究人员确定了在突触可塑性期间与AMPA型谷氨酸受体 (AMPARs) 相互作用的新蛋白质. 这些相互作用,特别是与NTM和OBCAM等IgLON蛋白的相互作用,调节突触中的AMPARs,影响学习和记忆.

相关概念视频

Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

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Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
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Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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