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Updated: Sep 11, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Published on: August 15, 2019

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与疾病相关的MRE11变体的差异表达揭示了不同的表型结果

McKenna B DeFoer1, Ahmed M Mostafa2,3, Andrea J Hartlerode1,2

  • 1Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

降低的MRE11-ATLD1水平会导致小鼠的贫血和骨髓衰竭,类似于低野生型MRE11. 失去MRE11的C端对MRN复合体 in vivo的功能影响很小.

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