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根据发育阶段对新生儿内出血的转录组反应

Elizabeth Wallace-Anthony1,2, Miriam Zamorano3,4, Hemendra J Vekaria3

  • 1Bioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, 29425, SC, USA.

bioRxiv : the preprint server for biology
|August 12, 2025
PubMed
概括

新生儿腹腔内出血 (IVH) 影响早产婴儿. 这项研究表明,大脑的

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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...