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Updated: Sep 11, 2025

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探索多发性硬化症中的真菌生物群:它对疾病发展和进展的影响

Ane Otaegui-Chivite^1,2, Miriam Gorostidi-Aicua^1,2, Laura Martins-Almeida^1,2

¹Group of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.

Frontiers in immunology

|August 12, 2025

概括

这项研究揭示了多发性硬化症 (MS) 患者的独特肠道真菌 (mycobiota) 概况,其中特定的真菌如马拉塞西亚与增加的残疾有关. 这些发现表明,真菌菌群在多发性硬化症的发病过程和潜在的治疗点中发挥了作用.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
神经科学是一个神经科学.

背景情况:

多发性硬化症 (MS) 是一种具有已知的遗传和环境影响的免疫媒介疾病.
人们越来越认识到肠道微生物群在MS中的作用,但真菌组成部分 (mycobiota) 仍未得到充分研究.

研究的目的:

为了描述MS患者肠道菌群的特征.
识别与MS风险因素,临床严重程度和饮食模式相关的真菌种群.

主要方法:

在巴斯克国家的MS患者和对照中的肠道菌群的表征.
分析真菌种群,MS风险因素,临床严重程度和饮食模式之间的关联.

主要成果:

多发性硬化症患者表现出更高的真菌多样性和丰富性,其中含有丰富的Saccharomyces,Torulaspora和Malassezia.
马拉塞西亚与增加的残疾密切相关,HLA-DRB1*1501等位基因影响了真菌生物组合.
观察到血生物标志物 (胆三酶,calprotectin) 和真菌之间的相互作用,饮食中的脂肪对MS患者的真菌生物组合产生不同的影响.

结论:

肠道菌群在MS的发病和进展中发挥着潜在的作用.
除了遗传和饮食因素之外,真菌生物标志物可以提高MS的理解,并为向治疗提供信息.

关键词:

在 HLA-DRB1*1501*1501 组合中.这是一种calprotectin.基托托里奥斯基化剂多发性硬化症多发性硬化症这就是我的mycobiome.

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