慢性病中脑源性神经营养因子表达的减少:综合临床和实验证据
Juan Chen1, Lili Fu1, Mengjin Li1
1Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Frontiers in molecular biosciences
|August 12, 2025
概括
脑衍生神经营养因子 (BDNF) 在慢性病 (CKD) 中显著降低. 这种降低与细胞有关,并且可能由 lnc RNA Bdnf-as.as. 进行表观遗传调节.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 慢性病 (CKD) 是一种进展性疾病,影响功能和新陈代谢.
- 大脑衍生神经营养因子 (BDNF) 对神经元和肌肉健康至关重要.
- 在CKD中降低BDNF背后的机制尚未完全理解.
研究的目的:
- 系统地评估CKD患者的BDNF水平.
- 研究CKD中的组织特异BDNF表达和调节.
- 探索 lnc RNA Bdnf-as 在CKD相关的BDNF减少中的作用.
主要方法:
- 对1549名患有CKD的参与者的元分析.
- 使用单边尿路阻塞 (UUO) 的小鼠模型进行实验验证.
- 组织的单细胞转录组分析和数据库分析.
主要成果:
- 分析显示,CKD患者的循环BDNF显著降低.
- UUO小鼠显示BDNF表达减少,特别是在近端管细胞,巨细胞和细胞中.
- 在CKD脏和UUO小鼠中观察到IncRNABdnf-as的升调,与降低的BDNF相关.
结论:
- 慢性病与显著降低的BDNF水平有关,无论是在脏内全身还是局部.
- 靠近管状细胞,巨细胞和细胞是CKD中脏BDNF减少的关键来源.
- lnc RNA Bdnf-as的升级可能会在CKD中表达BDNF表达的表观遗传抑制.
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