对甲基组与焦虑障碍的全方位关联进行系统审查
medRxiv : the preprint server for health sciences
|August 12, 2025
概括
焦虑障碍可能涉及DNA甲基化 (DNAm) 的变化,这是一个表观遗传标记. 这次对全甲基组关联研究 (MWAS) 的审查发现了初步证据,表明血液中的DNAm与焦虑有关,这表明免疫和炎症作用.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 焦虑障碍 (ANX) 是一个重要的公共卫生问题,影响日常生活和生活质量.
- 表观遗传修饰,如DNA甲基化 (DNAm),越来越多地被认为是它们在ANX病理生理学中的潜在作用.
- DNAm可以改变基因表达,提供一种分子机制,将环境因素和对ANX的遗传倾向联系起来.
研究的目的:
- 系统地审查和综合甲基组广泛关联研究 (MWASs) 调查人类焦虑症中DNAm变化的发现.
- 在现有的人类研究中识别与ANX相关的特定DNAm位点和基因.
- 评估ANX的MWAS发现的一致性和复制性.
主要方法:
- 在2025年5月,PubMed进行了系统的文献搜索,结果是804篇文章.
- 审查中包括了12项检查血液样本中ANX相关DNAm的研究.
- 数据合成的重点是识别显著相关的DNAm位点和基因,并评估跨研究的复制.
主要成果:
- 在包括的研究中,共有2023个DNAm位点,相当于985个基因,与ANX显著相关.
- 在所有研究中,没有DNAm网站显示出显著的复制;只有四个网站显示了名义复制.
- 鉴定的ANX相关的DNAm模式表明免疫和炎症途径的潜在参与,有一些性别特异性的影响.
结论:
- 本综述为全血和各种血细胞类型的DNA甲基化中与ANX相关的改变提供了初步证据.
- 缺乏可靠的复制突显了包括小样本大小和ANX当前MWAS分析变化的挑战.
- 未来的研究应该优先考虑更大的样本大小,标准化分析方法,纵向设计,以及在各种组织中对DNAm的调查,以全面了解ANX表观遗传学.
相关概念视频
Anxiety: Overview
348
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
348
Generalized Anxiety Disorder
204
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
204
Human Genetics
722
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
722
Genome-wide Association Studies-GWAS
14.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.2K
Stress and Mental Health
211
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
211


