在冲绳与大陆日裔美国人的癌症模式的特征:多民族队列研究
medRxiv : the preprint server for health sciences
|August 12, 2025
概括
来自冲绳和日本大陆的日裔美国人表现出明显的癌症率. 冲绳妇女患乳腺癌的风险较高,而男性患前列腺癌的风险较低,这表明生活方式之外的因素影响了这些差异.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 营养科学 营养科学
背景情况:
- 在冲绳和日本大陆之间,癌症发病率有所不同.
- 关于冲绳的日裔美国人与大陆血统的癌症发病率差异的数据有限.
- 以前的研究表明,生活方式和环境因素可能存在差异.
研究的目的:
- 为了研究冲绳和大陆日裔美国人之间的癌症发病率差异.
- 为了比较这两个群体之间的身体成分和血液生物标志物.
- 探索观察到的癌症差异的潜在促成因素.
主要方法:
- 利用缩小维度和姓氏分析识别了24,484个多民族队列,来自冲绳或大陆的日裔美国人.
- 使用Cox比例危险模型来比较癌症发病率.
- 在参与者的子集中分析了循环血液中的生物标志物水平和身体成分.
主要成果:
- 与日本大陆相比,冲绳的参与者表现出更高的BMI,更好的饮食质量,更高的能量摄入量,更多的酒精消耗,并且从未吸烟.
- 冲绳妇女患乳腺癌的可能性更高 (HR=1.36),而冲绳男性患侵袭性前列腺癌的可能性更低 (HR=0.67).
- 冲绳人呈现较低的脂肪素和较高的C反应蛋白,内脏脂肪组织面积,以及VAT与皮下脂肪组织面积的比率.
结论:
- 在日裔美国人中观察到的癌症发病率差异与日本报告的趋势一致.
- 身体成分,遗传或未测量的因素可能导致癌症风险差异,而不仅仅是生活方式.
- 需要进一步的研究来阐明影响这些人群癌症风险的因素的复杂相互作用.
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