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Linfeng Xin¹, Changqing Li², Hui Ni¹

¹Department of Breast and Thyroid Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, China.

Translational cancer research

|August 12, 2025

概括

分泌的蛋白1 (SPP1) 在乳头甲状腺癌 (THCA) 中高度表达,与临床特征和免疫细胞透相关. 这表明SPP1可能作为THCA的潜在诊断标记.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

分泌的蛋白1 (SPP1),一个SIBLING家族的成员,与癌症信号通路有关.
关于SPP1在乳头甲状腺癌 (THCA) 中的作用的研究有限.

研究的目的:

为了研究SPP1表达在乳头THCA中的表达.
确定SPP1和临床相关性之间的关系.
评估SPP1与THCA中免疫细胞透的关联.

主要方法:

利用TCGA和GTEx数据进行癌SPP1表达和预后分析.
在THCA中使用UALCAN和ROC曲线分析了微分SPP1表达.
通过GO和KEGG调查了SPP1的通路关联.
使用TIMER评估了SPP1与免疫细胞透的相关性.
通过免疫组织化学验证了SPP1表达和临床相关性.

主要成果:

在甲状腺癌中,SPP1的表达很高,与种族,阶段和亚型有关.
SPP1的表达与B细胞,CD4+T细胞,中性粒细胞,巨细胞和树突细胞具有正相关性.
共同表达的SPP1基因参与免疫反应和疾病.
免疫组织化学证实SPP1在乳头THCA中的升高,与囊状况和血液学参数有关.

结论:

在乳头THCA中SPP1表达的升高与临床病理特征有关.
SPP1显示出作为 papillary 甲状腺癌的诊断标记物的潜力.

关键词:

分泌的蛋白1 (SPP1) 的分泌.生物信息学是一种生物信息学.中性粒细胞与血小板的比率 (NPR)状甲状腺癌 (THCA) 状甲状腺癌 (THCA)

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