基于血细胞计数的炎症标记物与基于蛋白质的标记物相比,与糖尿病外围神经病变有更好的关联
Fu-Shun Ko1, Tsung-Hui Wu1,2, Guan-Yu Su1,2
1Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal of inflammation research
|August 12, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 与2型糖尿病患者的糖尿病外围神经病变 (DPN) 有关. 这种血细胞计数标记可能有助于识别患有DPN风险的个体,与基于蛋白质的标记物不同.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 糖尿病周围神经病变 (DPN) 是2型糖尿病的常见并发症,导致严重的残疾和影响生活质量.
- 慢性低度炎症与DPN病变产生有关,但各种炎症标志物的诊断效用仍然不清楚.
- 将基于蛋白质的标记物与血细胞计数衍生的比率进行DPN诊断的比较需要进一步的研究.
研究的目的:
- 为了比较血细胞计数衍生的炎症标志物 (中性粒细胞与淋巴细胞比率[NLR],血小板与淋巴细胞比率[PLR]) 与 DPN 的关联.
- 评估与DPN相关的基于蛋白质的炎症标志物 (介乐金-1受体对抗剂[IL-1Ra],高灵敏性C反应蛋白[hsCRP]) .
- 为了确定NLR或PLR是否与DPN比IL-1Ra或hsCRP更强烈地相关.
主要方法:
- 一项涉及137名2型糖尿病患者的横截面研究.
- DPN的诊断是基于密歇根州神经病学查仪器 (MNSI) 2或更高的得分.
- 评估包括体检,问卷和炎症标志物的实验室评估.
主要成果:
- 与对照组相比,与DPN患者的中性粒细胞和淋巴细胞的比率 (NLR) 显著增加 (P <0.05).
- 介素-1受体对抗剂 (IL-1Ra) 和高灵敏性C反应蛋白 (hsCRP) 水平在两组之间没有显著差异.
- 较高的NLR三位数与增加的DPN患病率相关,NLR是MNSI得分的独立预测因子,与HbA1c.一起.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 与2型糖尿病的糖尿病外围神经病变 (DPN) 有显著的关联.
- 基于蛋白质的炎症标志物 (IL-1Ra,hsCRP) 在本研究中没有显示出与DPN的明显关联.
- NLR可以作为一种简单,具有成本效益的生物标志物,用于识别患有DPN风险的患者,这需要进一步的纵向研究.
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