门静脉血栓塞在接受塞马格卢提德治疗的患者中
Mohammed F Farooqi1, Maria Khan1, Muhammad Arshad1
1Department of Internal Medicine, Tawam Hospital, Al-Ain, United Arab Emirates.
Qatar medical journal
|August 12, 2025
概括
类似葡萄糖类-1受体激动剂 (GLP1-RAs) 像塞马格卢提德一样会导致门静脉血栓形成. 医生应该考虑这种风险,特别是患有Janus酶2突变的患者,在开处方这些流行的减肥和糖尿病药物之前.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
背景情况:
- 肥胖和2型糖尿病 (T2DM) 是全球性的健康危机.
- 类似葡萄糖-1受体激动剂 (GLP1-RAs) 治疗T2DM和肥胖症,但可能会增加静脉血栓栓塞 (VTE) 的风险.
- 塞马格卢提德是用于T2DM和体重管理的广泛使用的GLP1-RA.
研究的目的:
- 报告患者肝脏内门静脉血栓塞的病例,患者接受了semaglutide治疗.
- 突出GLP1-RA使用与VTE之间的潜在关联.
- 强调医生对GLP1-RAs血栓形成风险的认识的重要性.
主要方法:
- 一个59岁的T2DM妇女的病例报告,接受了semaglutide治疗.
- 使用临床表现,体检,实验室测试和腹部计算机断层扫描 (CT) 扫描.
- 进行了血栓友测试.
主要成果:
- 这位患者在接受了6个月的西马格卢提德治疗后发生了肝内门静脉血栓形成.
- 没有已知的静脉瘤风险因素或家族血栓形成史.
- 检测到Janus酶2突变,这是血栓形成的潜在危险因素.
结论:
- 为了减肥,GLP1-RAs越来越多地被处方,需要对血栓形成风险的认识.
- 在开始GLP1-RA治疗之前,医生必须考虑潜在的血栓并发症.
- 这一案例强调了在GLP1-RAs患者中对VTE的警的必要性,特别是那些患有JAK2突变等风险因素的患者.
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