内微生物群:对癌症进展和治疗的影响
Zehang Xie1,2, Zhenguo Wu1,2, Yan Liu1,2
1Central Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Frontiers in microbiology
|August 12, 2025
概括
人体拥有多样化的微生物群,影响健康和癌症风险. 在瘤中发现的内微生物群可以推动癌症的进展,并影响治疗反应,提供潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 人体拥有多样化的微生物群,对生理过程和包括癌症在内的疾病风险至关重要.
- 甲基因组测序揭示了瘤微环境中的微生物群,影响瘤生长和治疗疗效.
- 内微生物越来越多地在各种癌症中被发现,包括胰腺,结直肠,肝脏,食道,乳腺和肺癌.
研究的目的:
- 提供癌症中内微生物群的全面概述.
- 讨论与内微生物群相关的流行,进展,检测和治疗策略.
- 探索研究内微生物群作为诊断和治疗目标的潜力和局限性.
主要方法:
- 文献综述和关于内微生物群的当前研究的综合.
- 对识别瘤组织中微生物存在的元基因组测序数据的分析.
- 评估通过内微生物群影响癌症发展和进展的拟议机制.
主要成果:
- 内微生物群可以通过粘膜破坏,邻近组织迁移或血液传播进入瘤组织.
- 这些微生物可能通过诱导DNA突变,激活致癌途径,改变药物代谢和促进转移来促进癌症.
- 瘤内微生物群的存在和作用是瘤微环境中的重要因素.
结论:
- 内微生物群是瘤微环境的关键组成部分,有可能影响癌症的发病,进展和治疗结果.
- 需要进一步的研究,以充分阐明内微生物群与癌症之间的复杂相互作用.
- 内微生物群有望成为癌症评估,预后和检测的潜在生物标志物,以及新的治疗点.
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