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患有和没有糖尿病神经病变的患者的系统性免疫炎症指数 (SII):一个横截面研究
Shubhransu Patro1, Vibha Sharma1, Arushi Choudhary1
1General Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus
|August 12, 2025
概括
糖尿病神经病症患者和没有糖尿病神经病症患者的全血细胞计 (CBC),中性粒细胞-淋巴细胞比率 (NLR) 和系统性免疫-炎症指数 (SII) 值相似. 然而,这项研究表明,
科学领域:
- 内分泌学和新陈代谢学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 糖尿病神经病变是2型糖尿病 (T2DM) 的常见并发症.
- 中性粒细胞-淋巴细胞比率 (NLR) 和全身免疫炎症指数 (SII) 反映了免疫炎症状态.
- 关于糖尿病神经病变中SII的研究有限.
研究的目的:
- 评估和比较糖尿病患者的全血细胞计 (CBC),NLR和SII,有和没有神经病变.
- 在糖尿病人群中对NLR和SII值进行相关联.
主要方法:
- 一项涉及193名成人糖尿病患者的横截面研究.
- 测量了血红蛋白,白细胞总数,中性细胞,淋巴细胞和血小板数.
- 计算的NLR (中性细胞/淋巴细胞) 和SII (NLR*血小板计数).
主要成果:
- 在有或没有神经病变的糖尿病患者之间没有观察到CBC,NLR或SII的显著差异.
- 在NLR和SII之间发现了强烈的正相关性 (r = 0.92,p < 0.001).
- 中位数HbA1c为8.61%,中位数糖尿病持续时间为11年.
结论:
- 可比较的CBC,NLR和SII值表明,根据这个队列中的神经病变状态,没有立即的炎症标志物差异.
- 结果受到样本大小和未调整的混变量 (如药物和并发症) 的限制.
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