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时间参数确定神经刺激的有效性定向的神经可塑性

Juliet J A Addo^1,2, Connor L Neifert^1,2, Tanya T T Danaphongse²

¹Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science, University of Texas at Dallas, Richardson, TX, USA.

Neurorehabilitation and neural repair

|August 12, 2025

概括

优化神经障碍的迷走神经刺激 (VNS) 需要了解时间参数. 适度的脉冲频率增强了VNS-依赖的可塑性,与爆发刺激不同.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
康复科学康复科学康复科学

背景情况:

神经刺激 (VNS) 与康复相结合,是神经疾病的有希望的治疗方法.
优化VNS需要了解刺激参数如何影响治疗效果.
之前的研究集中在强度上,但时间参数,如频率和脉冲分布的探索较少.

研究的目的:

为了研究不同时间刺激参数对迷走神经刺激导向可塑性的影响.
确定最佳的VNS参数,以提高皮质电路中的突触可塑性.

主要方法:

鼠在中等脉冲频率 (20,30,45赫兹) 或在运动任务期间进行突发刺激时接受了VNS.
在5天的训练后,使用皮质内微刺激来评估皮质运动表现.
假刺激作为对照进行了比较.

主要成果:

所有测试的中等脉冲频率 (20,30,45赫兹) 都显著增加了运动的皮质表现.
与假刺激相比,爆发刺激或均分布的脉冲并没有提高可塑性.
适度脉冲频率刺激在增强VNS-依赖的可塑性方面被证明是有效的.

结论:

VNS的时间动态对于其治疗效果至关重要.
适度的脉冲频率在增强VNS导向可塑性方面比爆发刺激更有效.
结果为设计神经治疗最佳VNS协议提供了指导方针.

关键词:

爆发爆发爆发爆发皮层重组,皮层重组.这种频率频率的频率频率.皮层内微刺激是一种内皮层微刺激.运动皮层的运动皮层.塑性的可塑性塑性阴道神经刺激的刺激.

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