双胞胎及其儿童,青少年或年轻人的癌症风险:更新的元分析和回顾性瑞典队列研究
Michael F G Murphy1, Jian-Rong He1, Rema Ramakrishnan2
1Nuffield Department of Women's and Reproductive Health, University of Oxford, The Women's Centre, John Radcliffe Hospital, Headington, Oxford, UK.
概括
双胞胎的儿童癌症风险降低,这种保护作用持续到年轻成人. 特定的瘤减少,特别是白血病和脏瘤,有助于这种持续降低癌症风险.
科学领域:
- 流行病学 流行病学
- 儿科瘤学 儿科瘤学
- 遗传学 是一个遗传学.
背景情况:
- 之前的研究表明,双胞胎的儿童癌症风险降低.
- 这种降低风险在青春期和年轻成年期的持续程度尚不清楚.
研究的目的:
- 为了确定双胞胎的儿童癌症风险降低是否持续到年轻成人.
- 确定有助于双胞胎整体风险降低的特定癌症类型.
主要方法:
- 更新了关于双胞胎儿童癌症风险的已发表研究的元分析.
- 分析了瑞典多代人登记 (1958-2002) 的数据,分析了年轻人到年轻人的癌症风险.
- 研究了与降低风险相关的特定瘤类型.
主要成果:
- 分析证实,双胞胎的儿童癌症发病率和死亡率减少了15%.
- 瑞典的数据显示,癌症风险降低,特别是白血病和脏瘤,从童年到年轻成人.
- 特定瘤类型的减少占总体风险降低的大部分.
结论:
- 在双胞胎中观察到总体癌症风险的持续降低,延伸到年轻成人.
- 特定瘤类型的风险降低,可能与子宫内生长模式有关,是这种持续效应的基础.
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