Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

403
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
403
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

3.1K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.1K
Ziegler–Natta Chain-Growth Polymerization: Overview01:17

Ziegler–Natta Chain-Growth Polymerization: Overview

3.4K
Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta...
3.4K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

263
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
263
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

2.6K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.6K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

192
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
192

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Nature of One-Electron σ-Bonds Probed by X-Ray Quantum Crystallography.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Nonlinear photophysics of PDA-based nanofluid: a potential candidate for two-photon photothermal therapy.

Nanoscale advances·2026
Same author

Aromatic amino acid based Schiff base copper(II) complexes as potential lung cancer therapeutics: Biological and antioxidant activity, DNA/BSA interaction, mesogenic properties, molecular docking and DFT study.

Journal of inorganic biochemistry·2025
Same author

Role of a Tunable σ-Hole-Mediated Chalcogen Bond in the Substrate Specificity of Methionyl-tRNA Synthetase.

The journal of physical chemistry letters·2025
Same author

A Mesogenic Glycyl-L-tyrosine Based Schiff Base Probe for Selective Dual Analytes (Zn<sup>2+</sup> and Cd<sup>2+</sup>) via Turn-on Fluorescence Responses and Its Application in Real Water Sample and Molecular Logic Gate.

Journal of fluorescence·2025
Same author

A novel insight into the femtosecond induced nonlinear response of monoamine neurotransmitters through experimental and in silico approaches.

Scientific reports·2025

相关实验视频

Updated: Sep 11, 2025

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.7K

高Z的多态形态是否具有转移稳定性? 从药物多态体的洞察力.

Amit Kumar Pradhan1, Athul Sudheendranath1, Jitesh Arora2

  • 1Department of Chemistry, Indian Institute of Technology Delhi, New Delhi, 110016, India. sajesh@iitd.ac.in.

Physical chemistry chemical physics : PCCP
|August 12, 2025
PubMed
概括

该研究调查了含有更多分子 (高-Z') 的晶体结构是否不太稳定. 分析了49种药物多态体,发现Z'和晶体稳定性之间没有直接联系.

更多相关视频

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

2.8K
Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
04:51

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

3.3K

相关实验视频

Last Updated: Sep 11, 2025

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.7K
Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

2.8K
Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
04:51

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

3.3K

科学领域:

  • 晶体学 晶体学是指结晶学.
  • 固态化学 固态化学
  • 计算化学是一种计算化学.

背景情况:

  • 理论上,高-Z'多态体不如低-Z'形式稳定.
  • 这种对称性-稳定性关系缺乏实验或计算验证.
  • 由于原子数量大,分析高Z'结构在计算上具有挑战性.

研究的目的:

  • 通过计算来评估Z'与药物多形态中的稳定性之间的关系.
  • 为了确定每个不对称单位中有更多分子的晶体结构是否本质上较不稳定.
  • 提供支持或反对对称性驱动分子晶体稳定性的基本假设的证据.

主要方法:

  • 使用CE-B3LYP方法进行高效的格子凝聚能 (LCE) 估计.
  • 在15种不同的药物中分析了49种多态体.
  • 评估的LCE,Kitaigorodskii包装指数 (KPI),分子体积和晶体密度.

主要成果:

  • 在Z' (不对称单位中的分子数) 和多态稳定性之间没有发现直接相关性.
  • 格子凝聚力的能量并没有随着Z'的增加而持续下降.
  • Kitaigorodskii包装指数,分子体积和晶体密度也没有显示出与Z'的明显趋势.

结论:

  • 高Z'多态体本质上较不稳定的假设在本研究中没有得到支持.
  • 药物多态体中的晶体稳定性并不是直接由不对称单元中的分子数量决定的.
  • 可能需要进一步的研究来确定控制多态稳定性的其他因素.