潜在的细胞巨乳病毒感染与ST段升高心肌梗塞后左心室功能受损有关
Luke Spray1, Alasdair McIntosh2, Peter J McCartney3
1Translational and Clinical Research Institute Newcastle University Newcastle Upon Tyne United Kingdom.
Journal of the American Heart Association
|August 12, 2025
概括
潜在的细胞巨乳病毒感染与ST段升高心肌梗塞 (STEMI) 后的较差结果有关. 患有STEMI和cytomegalovirus (CMV) 阳性的患者经历了 reperfusion 损伤和心脏功能降低.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 人类细胞巨乳病毒 (CMV) 是全球流行的一种疹病毒.
- 冠状病毒感染与心血管疾病风险增加有关.
- 对于CMV对ST段升高心肌梗塞 (STEMI) 结果的影响尚不清楚.
研究的目的:
- 调查潜伏的CMV感染与STEMI后患者结果之间的关联.
- 确定CMV阳性是否影响心肌再注血,心脏功能和STEMI后的生活质量.
主要方法:
- 354名来自T-TIME试验的STEMI患者用冷保存的样本进行了分析.
- 在基线样本中测量了细胞巨乳病毒 (CMV) IgG抗体标位.
- 评估的结果包括ST段分辨率,左心室喷射率和通过EuroQol5维视觉模拟尺度来评估生活质量.
主要成果:
- 冠状病毒阳性患者 (74.9%) 年龄较大,更有可能是非白人.
- 在CMV阳性个体 (38.7%对48.4%,P=0.032) 中,心肌再注血 (ST细分分辨率) 的成功率较低.
- 冠状病毒阳性与1周后 (42.6%对45.3%,P=0.006) 和3个月后 (47.8%对49.7%,P=0.033) 的左下心室射出分数相关,生活质量改善较差 (P<0.001).
结论:
- 潜在的细胞巨乳病毒感染与STEMI后心肌再注血受损有关.
- 在STEMI患者中,CMV阳性与左心室功能减弱和生活质量改善较少相关.
- 这些发现表明,CMV可能会对STEMI后的康复和长期结果产生负面影响.
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