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在人类关联皮层中,fMRI激活/失活和单个神经元反应的增加/减少之间存在密切的关系

Marie-Alphée Laurent¹, Corentin Jacques¹, Xiaoqian Yan²

¹Université de Lorraine, CNRS, IMoPA, Nancy, France.

|August 12, 2025

概括

研究人员研究了神经发射率如何与功能磁共振成像 (fMRI) 测量的大脑活动信号相关. 他们发现人类大脑中的面部选择神经元可以增加和减少它们的发射速度,澄清了fMRI信号的生理基础.

科学领域:

神经科学是一个神经科学.
认知神经科学认知神经科学
神经成像是一种神经成像.

背景情况:

功能磁共振成像 (fMRI) 中的血液氧水平依赖 (BOLD) 信号与潜在的神经发射率之间的关系尚未完全理解,特别是在人类关联皮质中.
以前的研究主要集中在与神经活动相关的BOLD信号的增加上,因此BOLD信号下降的解释不太清楚.

研究的目的:

直接对比神经元活动与fMRI信号在人类状回形 (FG) 的相邻大脑区域.
调查面部选择性神经活动是否仅与增加的神经发射有关,或者它是否也可能涉及降低发射速度.

主要方法:

利用了人类状回形中单个神经元 (单个单元) 的直接电生理记录.
使用频率标记刺激来客观地识别面部选择性神经元.
在面部感知过程中对比侧面FG (与fMRI增加相关) 和中间FG (与fMRI减少相关) 的神经元活动.

主要成果:

大约70%的记录的神经元被确定为面部选择性.
侧侧FG中的神经元在对面部反应时,选择性地增加了发射率.
介质FG中的神经元表现出对面部尖端活动的选择性减少,大约三分之一显示出基线活动的真正抑制.

结论:

人类面部选择性神经活动可以表达为增加和活跃抑制 (减少) 的尖端活动.
这些发现为fMRI信号的生理基础提供了关键的见解,解释了积极和消极的BOLD反应.
这项研究澄清了在面部感知过程中状回形中神经处理的性质.

关键词:

大胆的激活激活在 BOLD 中设置禁用.功能磁力共振成像 (fMRI) 是一种面部选择性面部选择性人类人类人类人类人类人类人类脑内录音脑内录音神经科学神经科学单个神经元单个神经元

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