益生菌预防肝脏脑病变后跨内肝脏移植系统的关节:一个随机对照试验
Xin Quan1, Ying Li1, Xiuling Ye1
1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
概括
这项研究发现,活组合Bifidobacterium和Lactobacillus药片可能降低经过状肝脏内移植系统 (TIPS) 程序后明显肝脏脑病变 (OHE) 的风险. 益生菌的使用也改善了肝硬化患者的认知功能.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 肝脏脑病变 (HE) 是一个常见的并发症,在肝硬化患者中,经过内肝脏移植系统分流 (TIPS) 后发生.
- 肠道失调与HE发展密切相关.
- 益生菌在预防TIPS后明显的HE (OHE) 中的预防作用尚不清楚.
研究的目的:
- 调查活组合双菌和乳酸菌片在降低TIPS后OHE发病率方面的疗效.
- 评估益生菌对TIPS患者认知功能的影响.
主要方法:
- 一个开放的,随机的,安慰剂对照试验,涉及142名接受TIPS的肝硬化患者.
- 参与者被分配给接受益生菌或安慰剂.
- 主要终点:TIPS后24周内OHE发生率;次要终点:认知功能测试 (NCT-A,DST) 和其他并发症.
主要成果:
- 与对照组相比,益生菌组的OHE发病率 (36.1%) 在益生菌组明显较低 (51.4%).
- 在没有OHE,肝移植或死亡的患者中,益生菌显著改善了数字符号测试 (DST) 和数字连接测试-A (NCT-A) 的得分.
- 两组之间没有观察到与肝硬化相关的其他并发症的显著差异.
结论:
- 活组合双菌和乳酸菌片可以作为预防性措施对OHE在肝硬化患者接受TIPS为水出血.
- 益生菌的管理表明,在这个患者队列中,认知功能得到了改善.
- 建议进行进一步的多中心研究来验证这些发现.
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