基于"特征性离子集"和化学测量的Saposhnikoviae Radix和Libonotidis Radix的分析
Xianrui Wang1,2, Fangliang He1,2, Haonan Wu1,3
1Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing, People's Republic of China.
Journal of mass spectrometry : JMS
|August 12, 2025
概括
这项研究引入了一种使用特征性离子集和化学测量的新方法,用于检测Saposhnikoviae Radix (SR) 中的Libonotidis Radix (LR) 改. 该方法可靠地确定了3%的LR改和两个市场样本被改.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 分析化学 分析化学
- 化学测量 化学测量 化学测量
背景情况:
- 萨波什尼科维亚雷迪克斯 (Saposhnikoviae Radix,SR) 和利博诺提迪斯雷迪克斯 (Libonotidis Radix,LR) 是重要的传统药物.
- 用SR与LR混SR是一个重要的质量控制问题.
- 现有的检测方法缺乏效率和丰富性.
研究的目的:
- 开发和验证一种化学测量方法,用于检测SR中的LR改.
- 提高伪造查的效率和可靠性.
- 为了建立SR和LR识别的特征性离子集.
主要方法:
- 液体染色学-质谱学 (LC-MS) 分析SR和LR样本.
- 特性算法提取以获得每个草药的"特征性离子集".
- 用于反匹配的化学测量分析和匹配指数 (MI).
- 为了验证,提取LR专有组件 (Xanthalin).
主要成果:
- 为SR和LR建立了一个可靠的"特征性离子集".
- 该方法成功地发现了3%的LR改.
- 两个市场盲目样本被证实是用LR. 造的.
- 克桑他林被确定为LR的专有成分.
结论:
- "特征性离子集"与化学测量相结合,提供了一种可靠和有效的方法,用于检测SR中的LR改.
- 这种方法显著丰富了现有的检测策略.
- 经过验证的方法提高了草药查效率.
关键词:
利博诺提迪斯 (Libonotidis Radix) 是一个有根性的植物.萨波什尼科维亚雷迪克斯 (Saposhnikoviae Radix) 是一个在UHPLC-QTOF-MSn伪造分析 伪造分析具有特征性的离子集.化学分析 化学分析更多相关视频
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