脊髓体积减少和晚年预测霍威尔-乔利体患者的败血症:一个回顾性队列研究
Kaori Uchino1,2, Yuya Nakagami3, Megumi Enomoto3
1Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, 480-1195, Japan. ksakai@aichi-med-u.ac.jp.
International journal of hematology
|August 12, 2025
概括
由Howell-Jolly体 (HJBs) 表示的功能性下,增加了感染风险. 减少脏体积和年龄较大是HJBs患者中败血症的独立预测因素.
科学领域:
- 医疗成像医学成像
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 功能性低缩症提高了感染易感性,即使没有脊髓切除术.
- 豪威尔-乔利体 (HJBs) 是公认的标记物,但脏体积对感染风险的预测作用尚未明确.
研究的目的:
- 为了研究体积和感染风险之间的关联,在HJBs的非切除术患者中.
- 确定体积是否是败血症和其他感染的独立预测因素.
主要方法:
- 从2014年至2024年对95名患有HJB的非脊髓切除术患者进行了回顾性分析.
- 通过计算机断层扫描 (CT) 测量体积,并与理想值进行比较.
- 单变量和多变量逻辑回归分析,以评估体积,年龄和感染结果之间的关联.
主要成果:
- 脏的中位体积明显低于理想体积 (210毫升) (34毫升).
- 48%的患者至少有一次感染.
- 年龄≥65岁,体积<34毫升是败血症的独立预测因素 (p <0.05).
- 年龄较大也预测了任何感染 (p=0.013),脏体积较低显示出趋势 (p=0.064).
结论:
- 脊髓体积减少和年龄较大是HJBs患者败血症的独立危险因素.
- 基于CT的脏体积测量可以帮助识别功能性下.
- 这些发现可以指导高风险患者的预防策略.
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