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在NAFLD中发现生物标志物:从代谢学和投票计数元分析的见解

Pallavi Mudgal¹, Sonu Kumar Gupta¹, Sunny Malik¹

¹Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India, 121001.

Metabolomics : Official journal of the Metabolomic Society

|August 12, 2025

概括

这项研究确定了非酒精性脂肪肝疾病 (NAFLD) 中的关键代谢变化. 特定的氨基酸和代谢物呈现变化的水平,为NAFLD进展和治疗监测提供了潜在的生物标志物.

科学领域:

代谢学代谢学代谢学
生物标志物发现发现
肝脏疾病研究肝脏疾病研究

背景情况:

非酒精性脂肪性肝病 (NAFLD) 是一种普遍存在的全球性肝病,通常与代谢综合征有关.
早期诊断和监测NAFLD至关重要,但由于缺乏验证的生物标志物而受到阻碍.
目前对NAFLD的诊断和预后工具需要改进,以有效管理疾病.

研究的目的:

从现有的NAFLD代谢学研究中收集和分析代谢物数据.
确定显著失调的代谢物,这些代谢物可以作为NAFLD的未来生物标志物.
了解特定代谢物在非酒精性脂肪肝疾病进展中的作用.

主要方法:

对过去13年的临床数据进行了系统的文献审查.
数据来自主要的生物医学数据库,包括MEDLINE,EMBASE和PubMed.
使用选票计数方法对来自NAFLD患者的血清/血液代谢学数据进行了半定量元分析.

主要成果:

在NAFLD患者中观察到氨基酸代谢的显著变化.
上调的代谢物包括瓦林,异黄素,谷氨酸,氨酸,氨酸,α-谷氨酸和氨酸.
下调代谢物包括甘氨酸,氨酸和氨酸,这表明NAFLD进展中的不同代谢概况.

结论:

在非酒精性脂肪肝疾病进展中,代谢物概况发生显著变化.
需要对代谢学研究进行标准化,并改进代谢数据库.
增加公共代谢学数据的可访问性对于推进NAFLD生物标志物发现至关重要.

关键词:

生物标志物生物标志物不同的代谢产物差异化进行元分析分析.代谢概况分析是指代谢概况分析.无酒精脂肪肝是一种非酒精性脂肪肝.

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