长期COVID定义中的可变性和公布的流行率的验证
Lauren E Wisk1, Michelle L'Hommedieu1, Kate Diaz Roldan1
1Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at the University of California, Los Angeles.
JAMA network open
|August 12, 2025
概括
根据美国大型队列研究中使用的不同定义,长期COVID的患病率有很大差异. 这凸显了为准确的诊断和研究而迫切需要一个标准化的定义.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 长期COVID的定义缺乏共识,使准确的流行率测量和研究工作复杂化.
- 临床护理和研究受到COVID被定义的时间的广泛变化所阻碍.
研究的目的:
- 从已发表的文献中使用多个定义来评估长期COVID的患病率.
- 评估现有的长期COVID定义与自我报告病例的敏感性和特异性.
主要方法:
- 展望型,多中心队列研究 (INSPIRE注册表) 参与了4575名18岁以上的SARS-CoV-2感染的参与者.
- 利用各种已发表的长COVID定义来计算感染后3个月和6个月的流行率.
- 将已发表的定义与自我报告的长期COVID进行比较,以进行敏感性和特异性分析.
主要成果:
- 长期COVID的患病率差异很大,从感染后3个月的30.84%到42.01%,以及感染后6个月的14.23%到21.94%.
- 与自我报告相比,公布的定义显示了低至中度的敏感性 (在3个月内高达66.32%) 但高的特异性 (在6个月内高达94.26%).
- 在不同定义和时间点之间观察到流行率估计的显著差异.
结论:
- 长期COVID流行率的广泛变化强调了对标准化,验证的定义的急需.
- 标准化定义对于改善临床认可,研究可比性和指导准确诊断和治疗至关重要.
- 需要进一步的研究来确定长期COVID的普遍接受的定义.
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