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Updated: Sep 11, 2025

CD Spectroscopy to Study DNA-Protein Interactions
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CD Spectroscopy to Study DNA-Protein Interactions

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在缺乏SMARCB1的肉瘤中对PGBD5依赖的DNA损伤的表观遗传向

Yaniv Kazansky1, Helen S Mueller1, Daniel Cameron1

  • 1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America.

The Journal of clinical investigation
|August 12, 2025
PubMed
概括

结合EZH2和ATR抑制剂显示出治疗诸如表皮状肉瘤等癌症的前景. 这种表观遗传疗法针对DNA损伤修复途径,改善了临床前模型中的反应.

关键词:
细胞生物学 细胞生物学修复DNA的修复DNA的修复药物治疗是药物治疗.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.在瘤学瘤学.

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