阿尔金牙和儿童牙预防:一个随机临床试验
JDR clinical and translational research
|August 12, 2025
概括
与化物相比,一个高度的阿基宁牙膏显著减少了腔. 较低度显示出与化物类似的结果,为空预防提供了可行的替代方案.
科学领域:
- 口腔健康研究 口腔健康研究
- 预防牙损伤 预防牙损伤
- 临床试验中的临床试验.
背景情况:
- 牙损是全球口腔健康的一个主要问题.
- 化物已被证明是有效的,以剂量依赖的方式对虫病有效.
- 需要新的,全面的预防策略.
研究的目的:
- 为了评估含有不同度的氨酸的牙膏的抗菌效果.
- 为了比较 arginine 牙膏与化 (NaF) 控制.
- 评估阿尔金宁作为化物替代品,用于预防虫.
主要方法:
- 一个为期2年的,第三阶段,双盲,随机对照试验.
- 6000名 (10-14岁) 患有活跃虫的儿童被随机分类.
- 测试了三个牙膏:8.0%的阿尔金宁,1.5%的阿尔金宁和0.32%的化 (NaF).
主要成果:
- 8.0%的阿基尼因牙膏显示,与对照组相比,腐烂,缺失和填充表面 (DMFS) 和牙 (DMFT) 的减少分别为26.0%和25.3%,在统计学上显著.
- 1.5%的阿金宁牙膏在DMFS和DMFT方面都显示出与NaF控制的非劣势.
- 在1.5%的氨酸和NaF对照组之间没有发现显著差异.
结论:
- 与NaF相比,含有8.0%阿尔金因的牙膏显著降低了虫病发病率.
- 使用1.5%的阿尔金因的牙膏相当于NaF减少.
- 氨酸牙膏是抗牙保护的有效替代品,提供无化物选择.
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