在POSEIDON中的PGT-A患者 - 观点和局限性
Jakub Wyroba1,2, Maria Barszcz1, Iwona Fajt1
1Malopolski Institute of Fertility Diagnostics and Treatment - KrakOvi, Krakow, Poland.
JBRA assisted reproduction
|August 12, 2025
概括
在POSEIDON组的患者表现出与非POSEIDON组患者相似的意愿进行前植入前遗传测试,以检测肺积分症 (PGT-A). 然而,对于POSEIDON患者来说,PGT-A的成功率显著较低,因为胚胎囊的数量较少,euploidy率较低.
科学领域:
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
- 不孕不育 不孕不育 不孕不育
背景情况:
- 波赛顿分类识别了在体外受精 (IVF) 预后不佳的患者.
- 前植入性遗传测试 (PGT-A) 是一种用于评估胚胎染色体完整性的工具.
- 了解不同患者群体的PGT-A结果对于个性化治疗策略至关重要.
研究的目的:
- 为了比较PGT-A在POSEIDON分类患者中的可行性和结果与年龄匹配的非POSEIDON对照.
- 评估在不同波赛顿群体中获得足够多的PGT-A胚胎囊的可能性.
主要方法:
- 对824名接受细胞内质精子注射 (ICSI) 的POSEIDON患者的回顾性分析.
- 与360名非POSEIDON对照患者进行比较,按年龄分层 (<35岁和≥35岁).
- 评估囊胚细胞发育,PGT-A测试率和euploidy率.
主要成果:
- 非POSEIDON<35岁组产生了PGT-A (5.1±2/周期) 最多的胚芽细胞,而POSEIDON IV的胚芽细胞最少 (0.6±0.3/周期).
- 在没有PGT-A指示 (POSEIDON I,III,非POSEIDON<35Y) 的组中,与有指示 (POSEIDON II,IV,非POSEIDON ≥35Y) 的组相比,PGT-A测试的频率明显较低.
- 在没有指示的群体中 (59%-64%) 的尤普洛伊迪率高于在有指示的群体中 (35%-41%),有显著差异 (p<0.001).
结论:
- 尽管他们的预后较差,但POSEIDON患者表现出与非POSEIDON患者相比,愿意接受PGT-A测试.
- 在POSEIDON患者中,整体PGT-A的成功率显著降低,主要是由于卵细胞或胚胎细胞不足以进行活检和较低的euploidy率,特别是在较老的年龄组 (≥35岁).
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