对微塑料潜在的发育和生殖毒性的系统审查
Seneca Fitch1, John Rogers1, Sue Marty2
1ToxStrategies.
概括
微塑料 (MP) 对生殖毒性的研究由于方法上的重大缺陷而缺乏可靠性. 目前的研究表明,偏见的风险很高,阻止了对潜在健康影响的结论.
科学领域:
- 环境毒理学环境毒理学
- 生殖毒理学 生殖毒理学
- 哺乳动物毒理学
背景情况:
- 微塑料 (MP) 越来越多地研究其对人类和生态的影响.
- 生殖和发育结果是MP毒性的关键研究重点.
- 评估MP暴露的基于健康的基准值至关重要.
研究的目的:
- 系统地审查和批判地评估关于微塑料生殖和发育毒性的哺乳动物研究.
- 评估现有微塑料研究中的方法严谨性和偏差风险.
- 确定关键的局限性,并提出未来的研究方向.
主要方法:
- 对报告生殖和发育结果的24项哺乳动物研究的系统综述.
- 综合选择,绩效和消耗偏差的批判性评估 (NTP OHAT框架).
- 评估研究设计,暴露特征,结果评估和颗粒分析.
主要成果:
- 所有审查的研究都获得了III级评级,这表明存在高偏差风险.
- 重要问题包括不良的暴露特征和不充分的结果评估.
- 缺乏验证的测试指南和不一致的粒子表征限制了可重现性.
结论:
- 目前关于微塑料生殖毒性的证据是不可靠的,因为方法上的限制.
- 内部和构造有效性不足以进行风险评估.
- 进一步的研究需要改进研究设计,标准化方法和强大的暴露特征.
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