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Updated: Sep 11, 2025

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西林加上脑素是对西林敏感性肠球菌菌的治疗选择吗?

Paula Bierge^1,2, Inmaculada Gómez-Sánchez^1,2, Cristina Garcia de la Mària³

¹Laboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.

The Journal of antimicrobial chemotherapy

|August 12, 2025

概括

西林与塞夫托林结合,对大多数对西林敏感的Enterococcus faecium菌株产生了协同效应. 这种组合可能为难以治疗的医院相关感染提供新的治疗选择.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

菌 (Enterococcus faecium) 是一个主要的医院相关的病原体.
治疗Enterococcus faecium感染是一项挑战.
针对对安培素敏感的E. faecium (ASEfm) 的安培素-头素组合的有效性还没有得到很好的定义.

研究的目的:

评估将安皮西林与 ceftriaxone 或 ceftaroline 结合对ASEfm菌株的有效性.
确定这些抗生素组合的协同作用和添加作用.

主要方法:

对来自复杂感染的十种ASEfm血流分离物的分析.
对 ceftriaxone,ceftaroline和cefotaxime进行抗生素敏感性测试.
时间杀死试验是为了评估安皮西林与 ceftriaxone 或 ceftaroline 结合的协同作用和添加作用.

主要成果:

在70% (7/10) 的ASEfm菌株中,安皮西林加上塞法托林显示出协同作用/添加作用.
西林加上 ceftriaxone 显示出较少明显的协同作用,在30% (3/10) 的菌株中产生影响.

结论:

西林与塞夫托林或塞夫特里亚结合,对一些ASEfm临床分离物具有协同活性.
这些组合代表了对抗ASEfm感染的潜在治疗策略.

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