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Updated: Sep 11, 2025

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
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客户端-架构相互作用抑制了客户端蛋白质在模型凝聚物中的聚合

Rashik Ahmed1,2,3,4, Rhea P Hudson4, Julie D Forman-Kay3,4

  • 1Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|August 12, 2025
PubMed
概括

细胞循环相关蛋白1 (CAPRIN1) 凝结物防止了化在肉瘤 (FUS) RNA识别因子 (RRM) 客户端的聚合. 卡普林1的相互作用屏蔽了FUS RRM,尽管度增加和展开,但抑制了聚合.

关键词:
卡普林 (CAPRIN) 是一个动物.在 FUS RRM 中.核磁共振光谱法 (NMR) 是一种光谱法.阶段分离的阶段分离.没有蛋白质的能源景观 无蛋白质的能源景观

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