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Updated: Sep 11, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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干扰素β增强剂的基因调控逻辑的特点是两种选择性部署的转录因子协同作用模式

Allison Schiffman1, Zhang Cheng1, Diana Ourthiague1

  • 1Signaling Systems Laboratory, Department of Microbiology, Immunology and Molecular Genetics, and the Institute for Quantitative and Computational Biosciences, University of California Los Angeles, CA 90095.

Proceedings of the National Academy of Sciences of the United States of America
|August 12, 2025
PubMed
概括

I型干扰素 (IFNβ) 基因表达受到转录因子 (TF) 的严格调节. 新的模型揭示了两个不同的TF协同模式,解释了针对病毒或细菌刺激的精确IFNβ控制.

关键词:
在 NFκBB 的情况下.布尔的逻辑门是布尔的逻辑门.干扰素调节因子 (IRF) 是指干扰素的调节因子.干扰子-β的干扰.热力学状态组合模型的模型.

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