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Updated: Sep 11, 2025

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging
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Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

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核结合蛋白的AlphaFold引导的结构分析

Xin Yang1,2,3, Haoqiang Zhu1,2,3, Liuxin Shi1,3

  • 1Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Nucleic acids research
|August 12, 2025
PubMed
概括

我们开发了一个基于AlphaFold的工具来识别核细胞结合蛋白,发现了ARID4A/B和RNF168.8. RNF168的二元化增强了其核酶体结合,影响了表观遗传调节.

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DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
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The nucleoid represents a structurally and functionally distinct region within prokaryotic cells, where the cell's DNA and associated proteins are housed. Unlike eukaryotic cells, prokaryotes lack a membrane-bound nucleus, and the nucleoid facilitates the organization and accessibility of the genetic material within this constraint. The DNA in most bacteria and archaea exists as a single, circular, double-stranded molecule that is highly compacted through supercoiling and interactions with...
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