预防多药耐药结核病:一个新时代的黎明
Gavin J Churchyard1,2,3, Susan Swindells4, Amita Gupta5
1Aurum Institute, Parktown, South Africa.
概括
预防多药耐药结核病 (MDR-TB) 的进展至关重要. 新证据表明,六个月的勒沃素是安全和有效的预防结核病在MDR-TB接触接触者.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 耐多药结核病 (MDR-TB) 是一个重大的全球卫生挑战,在抗菌素耐药性死亡方面有很大贡献.
- 患有MDR-TB感染的个体面临患有活跃结核病的高风险,需要采取预防策略.
- 缺乏随机的证据来指导开发结核病预防性治疗指南的MDR-TB.
研究的目的:
- 为了提供关于levofloxacin在预防家庭接触者暴露于MDR-TB的结核病的疗效和安全性的随机证据.
- 为更新的世界卫生组织 (WHO) 结核病预防治疗指南提供信息.
主要方法:
- 分析了两项最近完成的随机对照试验.
- 这些试验评估了每天给MDR-TB患者的家庭接触者六个月的levofloxacin的安全性和有效性.
主要成果:
- 六个月的每日勒沃素治疗方案被发现是安全和有效的预防结核病在MDR-TB暴露接触者的结核病.
- 这些发现代表了第一个支持这种预防治疗的随机证据.
结论:
- 世界卫生组织更新了结核病预防治疗指导方针,强烈建议在暴露于MDR-TB的接触者中服用六个月的勒沃素.
- 开发新的,较短的治疗方案对MDR-TB感染的未来管理具有前景,等待安全性和有效性的证明.
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