在肉和人类临床Enterococcus分离物之间,NarAB的不同种群结构和基因组背景
Jayanth Balakuntla1, Shabbir Simjee2, Shrinivasrao P Mane3
1Elanco Innovation and Alliance Centre India LLP, Bengaluru, India.
The Journal of antimicrobial chemotherapy
|August 12, 2025
概括
禽类Enterococcus faecalis和Enterococcus faecium中的NarAB基因并没有共同选择抗生素耐药性. 这表明家禽不太可能将耐药性基因转移到人类身上,这支持农民继续获得离子体菌定位剂.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 基因组学就是基因组学.
背景情况:
- 报道表明,NarAB基因与阳离子子菌体耐药性和Enterococcus中抗生素耐药性的共同选择有关.
- 在这种情况下,Enterococcus faecalis和Enterococcus faecium是关键物种.
研究的目的:
- 来自各种来源的Enterococcus物种中调查NarAB基因的流行情况.
- 为了确定NarAB基因是否对禽类隔离物中临床相关的抗生素耐药性基因进行共同选择.
主要方法:
- 对Enterococcus faecalis (n=7731) 和Enterococcus faecium (n=20594) 的公开可用的基因组进行分析.
- 专注于肉,火,狗和人类临床感染的基因组.
主要成果:
- 在 brojiler 隔离物 (26% E. faecalis, 39.2% E. faecium) 中,NarAB 基因的流行率高于人类临床隔离物 (2.8% E. faecalis, 2.0% E. faecium).
- 在家禽分离物中,在NarAB附近没有发现医学上重要的抗生素耐药性的基因,这驳斥了共同选择的说法.
- 在NarAB附近的基因组模式和序列类型在家禽和人类分离物之间有所不同.
结论:
- 携带NarAB的禽类Enterococcus分离物不太可能对人类感染产生抗性基因.
- 调查结果支持养殖者和兽医继续获得离子体菌定位剂.
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