在系统性自身免疫性类风湿性疾病 (SARDs) 中自我报告的认知功能障碍和记忆障碍:INSPIRE队列的混合方法分析
Avni Varshney1, Thomas A Pollak1, Arjoon Arunasalam1
1Institute of Psychiatry, Psychology and Neuroscience, King's College London, and South London and Maudsley NHS Foundation Trust, London, UK.
Rheumatology (Oxford, England)
|August 12, 2025
概括
患有系统性自身免疫性类风湿性疾病 (SARDs) 的患者,特别是系统性红斑狼 (SLE),不分化的结缔组织疾病 (UCTD) 和Sjögren,会出现显著的记忆障碍. 这种认知功能障碍会影响日常生活和福祉,强调需要有针对性的干预措施.
科学领域:
- 类风湿病学 类风湿病学
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 系统性自身免疫性风湿性疾病 (SARDs) 可以影响多个器官系统,包括中枢神经系统.
- 认知功能障碍,特别是记忆障碍是SARD中经常报告但未经研究的症状.
- 了解认知问题的患病率和影响对于全面的患者护理至关重要.
研究的目的:
- 为了调查自我报告的认知功能障碍,专注于记忆障碍,在患有各种SARS的患者中.
- 检查认知功能障碍与人口,临床和心理社会因素之间的关联.
- 探索认知功能障碍对患者日常生活和福祉的影响.
主要方法:
- 一种混合方法的方法,结合了定量调查 (1853名SARD患者,463名对照) 和定性深入访谈 (67名患者).
- 经过验证的工具,包括每日记忆问卷修订 (EMQ-R),用于定量评估.
- 进行了统计分析 (Kruskall-Wallis,Spearman相关性) 和面试数据的主题分析.
主要成果:
- 患有系统性红斑狼 (SLE),不分化的结缔组织疾病 (UCTD) 和Sjögren病的患者报告记忆障碍的比率更高.
- 记忆障碍与疾病活动和其他神经精神症状有积极的关联,与幸福感有负面的关联.
- 定性数据显示,对日常功能,社交互动,自尊和心理健康有显著的不良影响,对临床医生可能报告不足.
结论:
- 在特定的SARD (SLE,UCTD,Sjögren's) 中普遍存在显著的记忆障碍,对患者的生活质量产生负面影响.
- 认知功能障碍与疾病活动和心理健康有关,需要量身定制的干预措施.
- 彻底的患者评估至关重要,因为认知问题可能被低估,并且比临床上认可的更为普遍.
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