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Updated: Sep 11, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

424

通过PRC2抑制染色质,导致基因表达减少,导致CD8 T细胞耗尽的关键特征

Parisa Samareh1,2, Paula Agudelo-Garcia1,2, Zhen Zhang1,2

  • 1Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Journal of immunology (Baltimore, Md. : 1950)
|August 12, 2025
PubMed
概括

慢性抗原暴露会导致T细胞耗尽,损害疾病清除. 这项研究揭示了在耗尽的CD8T细胞中的表观遗传变化,特别是增加的H3K27me3和PRC2活性,提供了潜在的治疗点.

关键词:
癌症 癌症 癌症 癌症 癌症在这种情况下,染色染色素疲 疲 疲 疲 疲感染感染的感染.镇压 镇压 镇压 镇压

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