HPV 疫苗接种与免疫媒介疾病风险的关联
Qianru Zhang1,2, Renin Chang3,4,5, James Cheng-Chung Wei6,7,8,9,10
1Department of Rheumatology and Immunology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
QJM : monthly journal of the Association of Physicians
|August 12, 2025
概括
人类乳头瘤病毒疫苗接种 (HPVV) 与发展免疫媒介疾病的风险降低有关. 这种保护作用在9-45岁的女性中被观察到,特别是在使用9价值疫苗时.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 人类乳头瘤病毒疫苗接种 (HPVV) 与免疫媒介疾病之间的关系正在争论中.
- 需要进行研究,以了解HPV对9-45岁女性各种免疫介导疾病的影响.
研究的目的:
- 调查HPV和免疫媒介疾病发生率之间的关联.
- 探索年龄,疫苗类型和种族对这种关联的潜在影响.
主要方法:
- 使用美国TrinetX数据 (2018-2022) 进行的一项大型队列研究包括208,638名接种HPVV疫苗的女性,并与对照对照.
- 倾向性得分匹配和Cox比例危险回归被用来分析免疫介导疾病的发病率.
- 小组分析考虑了年龄,种族,生活方式因素和HPV疫苗类型.
主要成果:
- HPVV 与类风湿性关节炎,全身性红斑狼,皮肤肌炎,乳病和1型糖尿病风险显著降低有关.
- 还观察到炎症性肠道疾病的风险降低.
- 保护作用在9-26岁的女性和接受9性HPV疫苗的女性中更为明显.
结论:
- 人类乳头瘤病毒疫苗接种与患上几个免疫媒介疾病的风险降低有关.
- 这些发现表明HPV的潜在免疫调节作用,需要进一步调查.
更多相关视频
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.8K
13:56A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
11.3K
相关概念视频
Vaccinations
45.3K
Overview
45.3K
Cancer Vaccines
509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
509
Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
Autoimmune Disorders
672
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
672
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
