患者报告的结果措施与客观的炎症性肠病活动措施的相关性很差:系统性审查
Xavier Calvet1,2,3, Maria Giovanna Ferrario4, Vanessa Marfil4
1Gastroenterology Unit, Parc Taulí University Hospital, Parc Taulí Research and Innovation Institute (I3PT-CERCA), Sabadell, Spain.
Journal of Crohn's & colitis
|August 12, 2025
概括
患者报告的结果测量 (PROM) 提供了对炎症性肠病 (IBD) 控制的补充洞察力,但不能取代客观评估. 未来的研究旨在加强PROM,以提高评估IBD活动的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 炎症性肠病 (IBD) 管理依赖于对疾病活动的客观测量.
- 患者报告的结果指标 (PROM) 提供了患者对疾病控制的看法.
- 调查PROM和客观IBD活动标志物之间的相关性至关重要.
研究的目的:
- 调查患者报告的结果指标 (PROM) 与炎症性肠病 (IBD) 活动的客观指标之间的相关性.
- 评估PROMs在评估克罗恩病 (CD) 和性结肠炎 (UC) 疾病活动中的实用性.
主要方法:
- 一个系统的文献审查进行到2022年6月.
- 搜索包括PubMed,Scopus和Web of Science的数据库.
- 对19项研究进行描述性分析,对临床,内镜和实验室标记进行PROM评估.
主要成果:
- 在PROM和内镜评分 (CD中的SES-CD,UC中的MES) 之间观察到微弱的正相关性.
- 在CD和UC中,PROMs与实验室标记物如便calprotectin (FCP) 和C反应蛋白 (CRP) 的一致性有限.
- 研究设计中的异质性限制了结构化分析.
结论:
- 目前的PROM为IBD控制提供了有价值的补充见解,但不能取代客观措施.
- 需要进一步的研究来完善PROM并开发复合指数,以提高IBD评估的准确性和实用性.
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