常见感冒与防范SARS-CoV-2感染有关
Camille M Moore1,2,3, Elizabeth A Secor1, Jamie L Everman1
1Center for Genes, Environment, and Health, National Jewish Health; Denver, CO, USA.
常见的呼吸道感染,如鼻病毒,可能会防止严重的SARS-CoV-2. 儿童经常接触犀牛病毒可能会导致他们的防御,这解释了与成年人相比,COVID-19的结果较温和.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 成年人比儿童面临更高的SARS-CoV-2症状和严重的风险.
- 儿童的潜在保护可能源于呼吸道抗病毒防御的增强,主要是由频繁的呼吸道病毒感染引起的.
研究的目的:
- 为了调查常见的呼吸道病毒感染是否能预防SARS-CoV-2.
- 探索这种保护背后的呼吸道分子机制.
主要方法:
- 人类流行病学和应对SARS-CoV-2队列的病例队列和病例控制分析.
- 从1,156名参与者中检测了10,493个鼻子拭子,检测了21种呼吸道病原体.
- 在犀利病毒感染前和感染期间,对拭子进行RNA测序.
主要成果:
- 犀牛病毒感染将SARS-CoV-2风险降低了48%,病毒载量降低了9.6倍.
- 57个基因的高感染前表达,包括24个抗病毒基因,与较低的SARS-CoV-2病毒载量相关.
- 与成年人相比,儿童的抗病毒基因表达更高,鼻病毒感染风险增加.
结论:
- 犀牛病毒感染诱导抗病毒气道基因表达,降低SARS-CoV-2感染风险.
- 频繁的鼻病毒感染可能会增强这种保护性,从而导致儿童COVID-19的发病率较轻.
- 研究结果表明,儿童和成人之间存在SARS-CoV-2严重程度差异的机制.
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