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Updated: Sep 11, 2025

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凯胺加上纳尔特雷克松对与酒精使用障碍并发性严重抑郁症的抗抑郁药物疗效:随机对照试验

Gihyun Yoon^1,2, Brian Pittman², Elizabeth Ralevski^1,2

¹Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, United States.

The international journal of neuropsychopharmacology

|August 12, 2025

概括

与单独使用胺治疗的大型抑郁症 (MDD) 和酒精使用障碍 (AUD) 的胺治疗添加纳勒,与单独使用胺治疗相比,显示出类似的抗抑郁药和抗酒精作用. 片受体阻塞没有改变胺的作用.

科学领域:

精神病学是一个精神病学.
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

大型抑郁症 (MDD) 和酒精使用障碍 (AUD) 经常同时发生,并且难以有效治疗.
胺,一个NMDA受体对抗剂,显示抗抑郁性质,但其在并发性MDD和AUD的疗效需要进一步调查.
在胺的抗抑郁作用中阿片类受体刺激的作用尚未完全理解.

研究的目的:

为了比较胺加纳尔特雷克松与胺加盐酸和米达佐拉加盐酸在治疗并发性MDD和AUD的疗效.
评估添加纳尔特雷对抑郁症严重程度和酒精消费的影响.
探索阿片类受体对抗作用对胺治疗效果的贡献.

主要方法:

一个三臂,随机,双盲,并行组研究.
65名患有MDD和AUD的成年参与者每周接受4次胺加纳尔特雷,胺加盐水或米达佐拉姆加盐水输注.
主要结局包括抑郁症严重程度 (MADRS尺度) 和酒精戒断.

主要成果:

所有组都显示出显著的抑郁缓解 (>80%).
两组之间没有观察到抑郁症严重程度 (MADRS) 或与酒精有关的结局的显著差异.
与米达佐拉姆相比,胺组表现出更长时间的抗抑郁作用,焦虑和生活质量得到了更大的改善. 胺加纳尔特雷克松显示出比胺加盐水更大的焦虑改善.
没有报告任何严重的不良事件.

结论:

氨酸在治疗并发性MDD和AUD方面表现出有效性,具有持续的抗抑郁作用和改善焦虑和生活质量.
将纳尔德添加到氨酸中没有改变其抗抑郁药或抗酒精作用,这表明阿片类受体对抗性不会显著影响氨酸在这个人群中的治疗作用.
这些发现支持胺作为AUD的MDD的潜在治疗方法,而阿片类药物途径的作用需要进一步研究.

关键词:

酒精使用障碍饮酒障碍临床试验临床试验临床试验临床试验临床试验胺基氨酸是什么胺基氨酸大型抑郁症主要是抑郁症.纳尔特雷克森 (Naltrexone) 是一种可以药物治疗药物治疗

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